Ph.D. student (f/m/d) or PostDoc (f/m/d) To study amino acid transporter structure and function

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Our team is looking for a

Ph.D. student (f/m/d) or PostDoc (f/m/d)
To study amino acid transporter structure and function

A Ph.D. student position (65% TVL E13) for 36 months or a PostDoc position (100% TVL E13) for 27 months is available in the group of PD Dr. Ulrich Hammes at the Chair of Plant Systems Biology at the School of Life Sciences at TUM in Freising-Weihenstephan jointly with the group of Prof. Olga Boudker at Weill Cornell Medical College.

Research and Tasks

We want to study proton-coupled amino acid transporters from plants. We want to solve the structures of several transporters to understand their transport mechanisms and biophysical properties. The insights gained from the biochemical work will be transferred to plants with the aim of increasing nitrogen efficiency by improving transport through rational design.

Your Profile

A strong background and interest in protein expression, different expression systems, and purification of membrane proteins, as well as transport physiology, particularly electrophysiology, to characterize transporters are indispensable. A keen interest in plants is desirable. The funding scheme requires the successful candidate to spend time in both institutions. The will to travel and exposure to different lab and social environments is also of critical importance.

We offer

Weill Cornell Medical College and TUM are elite research environments and provide access to state-of-the-art techniques and equipment required to perform research at the leading edge of science.

Website of the Chair of Plant Systems Biology at TUM: http://sysbiol.wzw.tum.de

Website of the Boudker lab at Weill Cornell Medical College: https://www.boudkerlab.com

Application

We are looking forward to your application, including a letter of motivation describing your skills and research interest, your CV, and contact information for two references.

Please send your application documents in a single PDF to This email address is being protected from spambots. You need JavaScript enabled to view it.

The position is available immediately. The selection process will remain open until a suitable candidate is found.

TUM aims to increase the proportion of women; qualified women are therefore strongly encouraged to apply.

The position is suitable for severely disabled persons. Severely disabled applicants will be given preference in the event of otherwise essentially equal suitability, ability and professional performance.

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity/Minorities/Females/Vet/Disabled employer.

Data Protection Notice

As part of your application for a position at the Technical University of Munich (TUM), you will be providing personal data. Please refer to our data protection notice in accordance with Article 13 of the General Data Protection Regulation (GDPR) regarding the collection and processing of personal data in the context of your application. By submitting your application, you confirm that you have read TUM's data pro

PhD Student or Postdoc (f/m/x) “Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

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PhD Student or Postdoc (f/m/x) “Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

YOUNG SCIENTISTS

Job Code: 60-23

Job Offer from December 21, 2023

The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.

The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) is inviting
applications for a

PhD Student or Postdoc (f/m/x)
in the field of
“Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

Possible projects are variational free energy methods, thermodynamics of solvation shells, Markovian thermodynamics, as well as functional mechanisms of the ribosome, fatty acid synthase, CRISPR/Cas, or intrinsically disordered proteins.

Please indicate in your application which of the above listed projects is most intriguing for you.

Your profile

The successful candidate has a keen interest and strong skills in computational molecular physics and statistical mechanics, and also a great interest in interdisciplinary research and collaboration with experimental groups.

PhD students hold (or expect to complete soon) a Masters or equivalent degree in physics, mathematics or any related field; correspondingly, Postdocs hold a PhD or equivalent degree in the above mentioned fields.

What we offer

  • State of the art on-site high performance / GPU compute facilities
  • Competitive research in an inspiring, world-class environment
  • A wide range of offers to help you balance work and family life
  • Further training opportunities and free in-house language courses

The group language is English, so no German language skills are required – but it is a great opportunity for you to learn German! The historic city of Göttingen, located in the heart of Germany, offers great outdoors and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.

Position details

PhD students will have the opportunity to participate in one of several available PhD programs, with three years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and, therefore, encourages applications from such qualified individuals. The Max Planck Society strives for diversity and gender equality and welcomes applications from all backgrounds.

Application

Applications will be reviewed on a rolling basis until the position is filled. Please submit your application including a cover letter (explaining background and motivation), a CV and transcripts (translated to English or German, if applicable) preferably via e-mail and as a single PDF file to:

This email address is being protected from spambots. You need JavaScript enabled to view it.

Max-Planck-Institute for Multidisciplinary Sciences
Department of Theoretical and Computational Biophysics
Prof. Dr. Helmut Grubmüller
Am Faßberg 11
37077 Göttingen
Germany

Social Media: @CompBioPhys

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

 

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

As part of the Cluster of Excellence ‘Unifying Systems in Catalysis’ (UniSysCat), the Horch research group ‘Ultrafast Dynamics in Catalysis’ aims to understand complex catalytic systems and superordinate reaction networks by using an integrated approach of advanced spectroscopic and theoretical methods. In particular, we are interested in metalloenzymes – huge metal-containing proteins that catalyse, e.g., the conversion of small molecules like H2 and CO2.

More details about the Horch research group and UniSysCat, can be found here:

https://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-horch/

https://www.unisyscat.de/people/current-group-leaders/horch-marius/

Project Description

To establish a “greener” chemistry based on living cells, we envisage the design of a cellular system that uses waste material and unlimited sun light for sustainable hydrogen production. Developing such a system requires a detailed understanding of all involved processes on the molecular and cellular level. Together with multiple partners, the successful candidate will develop a multichannel in vivo spectroscopy approach to target the involved biological macromolecules, relevant cytoplasmic factors, and the interplay of these two types of cellular key determinants. Focusing on the hydrogen-producing enzyme, a [NiFe] hydrogenase, this strategy will expand previously established in vivo spectroscopic strategies by introducing ultrafast and multidimensional infrared techniques that yield details insights into structure, dynamics, and environmental interactions. In total, this approach will provide a guideline for the rational design of cellular catalytic systems.

Relevant Publications

https://doi.org/10.1002/anie.201002197

https://doi.org/10.1039/C5CP02447A

https://doi.org/10.1039/C9SC02851J

Field of Work

- Ultrafast nonlinear infrared spectroscopic experiments (2D-IR and IR-IR pump-probe)

- Execution of such experiments at international research facilities

- Analysis and interpretation of spectroscopic data

- Interdisciplinary cooperation with other members of the overarching team project

- Manipulation and handling of delicate biological samples supplied by collaboration partners

- If beneficial, calculation of infrared spectroscopic observables by quantum chemical methods

- Writing of scientific articles for publication in international peer-reviewed journals

- Presentation of research results at international scientific conferences

We Offer

We offer a position in an exciting and challenging project with the opportunity to obtain a PhD. The project will be pursued in a dynamic, international, and cooperative team of scientists from different fields of research. The project is also part of UniSysCat, which provides the opportunity to engage in interdisciplinary collaborations and build scientific networks. As a first-class location for science and a vibrant global city, Berlin offers an ideal framework.

Requirements

Master’s degree (or equivalent) in the field of physics, physical chemistry, biophysics or similar

Desirable Qualification

Expertise and experience in the following areas is desirable, but knowledge in all them of them is not mandatory. Applications from candidates that are willing to learn about the listed aspects are welcome

- Excellent university degree

- Experience with infrared spectroscopy or vibrational spectroscopy in general

- Experience with ultrafast nonlinear spectroscopy and data analysis

- Experience with (pulsed) laser sources and (nonlinear) optics

- Experience with quantum chemical calculations

- Experience with the handling of biological and/or oxygen-sensitive samples 

- Knowledge in biological, inorganic, and/or photo chemistry

- Programming skills, preferably in Python

- Ability to work independently and as part of an interdisciplinary team

- Creativity, enthusiasm, and a genuine interest in the advertised project

- Fluency in English (spoken and written)

 

Starting Date

As soon as possible

Application Deadline

13 March 2023. Applications sent after the deadline will be considered until the position is filled.

Funding

TV-L E13 (67 %) until 31 December 2025, funding by the DFG via UniSysCat, funding extension from other sources is possible

Selection Process

Please send your documents and requests to Dr. Marius Horch (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Further details can be found here:

https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/english/PH-Horch-UniSysCat-Cells-2023-E.html

PhD Position Topic: Investigation of the structure and dynamics of the ghrelin/GHS receptor complex

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PhD Position

Topic: Investigation of the structure and dynamics of the ghrelin/GHS receptor complex

beginning: at the earliest possible date, payment according to TVL13 (65%)

working group: Prof. Dr. Daniel Huster, Institute of Medical Physics and Biophysics,

                              Härtelstr. 16-18, 04107 Leipzig

The peptide hormone ghrelin plays a key role in food intake and body weight regulation. Ghrelin binds and activates the GHS receptor (GHSR) representing an important pharmacological target. In the project, structural details of the dynamic interaction of ghrelin with GHSR and its conformational dynamics in different states of activation will be studied. We use a combination of experimental methods of nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulation tools in collaboration with projects of the CRC 1423 “Structural Dynamics of GPCR Activation and Signaling”. Alterations of GHSR structure and dynamics, which occur upon binding of the agonist ghrelin, will be studied to address the mechanism of receptor activation and signal transduction to downstream transducer proteins. To understand the high basal activity of GHSR, we will plan to study the loss-of-constitutive-activity Ala204Glu GHSR mutant as downregulation of this basal activity represents a pharmacological goal.

The AG Huster at the Institute of Medical Physics and Biophysics is an international group of ~15 people from different backgrounds. Our values are gender equality, mutual appreciation and support of each other to create a constructive and positive working atmosphere. A video of our group can be found here:

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The candidate should hold a master’s degree in biochemistry, chemistry, biophysics or a relevant field.

Applications with a cover letter, a CV, all relevant university certificates and contact information of potential referees should be sent as a single PDF file per email to Daniel Huster, This email address is being protected from spambots. You need JavaScript enabled to view it..

PhD Project on Interaction of Rhodopsin and Cryptochrome as the Basis for Opto-Magnetic sensing in Birds

PROJECT DESCRIPTION
Magnetosensing is mandatory for seasonal long distant flights of birds and butterflies from north to south
and back and to find the home places of previous years. During the past 40 years strong evidence has
been collected that for magnetic orientation blue light sensitive Cryptochromes within the retina of the
eyes are responsible.
However, since birds are able to navigate at very low light intensities during the night an interaction of the
abundant rhodopsins with the only scarcely expressed Cryptochromes has been suggested.
In the open project unusual rhodopsins of birds and butterflies and their interaction with Cryptochromes
will be studied and characterized in detail in order to understand animal magnetic sensing. Behavioral
studies will be carried out in collaboration with behavioral zoologists.
KEYWORDS
Magnetosensing, Photobiology, unusual rhodopsins, flavin-based photoreceptors, UV-Vis and infrared
spectroscopy, EPR, ultra-fast spectroscopy.
Entry requirements
The applicant needs a MSc. degree (or equivalent) in biochemistry, biophysics, biology or related fields.
Basic skills in molecular biology are mandatory. The applicant should be prepared to work in a highly
interdisciplinary team with strong international collaborations.
LOCATION
Humboldt Universität zu Berlin, Institute of Biology, Experimental Biophysics, Invalidenstraße 42, D-10115
Berlin
STARTING DATE
Between August and December 2023
FUNDING
Four years of funding (3+1, three years with the possibility to extend for one year)

2023-HFA-Advertised-position_Hegemann.pdf (hector-fellow-academy.de)