PhD position (m/f/d) in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases (65% TV-L E13, 36 month).

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PhD position (m/f/d) in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases (65% TV-L E13, 36 month).

The Kozuch group investigates the function of biomedically relevant (membrane) proteins with a special focus on electrostatic interactions that shape the formation of functional motifs. The methodological approach is based on a combination of (nanoscopic) vibrational spectroscopy supplemented by the use of model membrane systems, biochemical methods and computer-aided simulations. After completing his doctoral thesis in biophysical chemistry at the Technical University of Berlin, Dr. Jacek Kozuch did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at Freie Universität Berlin.

This DFG-funded project aims to research how specific interactions with membranes for folding or misfolding of, e.g., β-amyloid or islet amyloid polypeptide can lead to neurodegenerative diseases. For this purpose, surface-enhanced (SEIRAS) and AFM-based nano-infrared spectroscopy (nanoIR) in combination with model membrane systems will be used to track folding trajectories and control them through various boundary conditions.

We offer:

  • the opportunity for a PhD within the stimulating, interdisciplinary and

  international environment of Freie Universität Berlin,

  • the entry into fascinating and biomedically relevant topics of molecular

  Biophysics,

  • the use and further development of modern vibrational spectroscopic methods.

Requirements and Qualifications

Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, biochemistry or in one of the related natural sciences.

We are looking for candidates with:

Experience with vibrational spectroscopic methods and/or atomic force microscopy; handling biological samples (e.g., proteins); willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; fun and fascination with science, especially in the field of molecular biophysics.

The area of ​​responsibility includes:

  • the independent conduction of this scientific project,
  • the biochemical preparation of protein/peptide samples and the construction of

  membrane model systems,

  • the implementation of nanoscopic and surface-enhanced infrared spectroscopy

  measurements,

  • participation in international conferences.

Selection process

Please contact Dr. Jacek Kozuch if more information is required (This email address is being protected from spambots. You need JavaScript enabled to view it. / +49 (0)30 838 64888) or visit the FU Berlin homepage: https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/wiss/20_fb-physik/PH-KO5464-5.html

Applications (including cover letter, CV, certificates, one letter of recommendation as a single PDF) should be sent electronically by e-mail to Dr. Jacek Kozuch: This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it..

Universitätsprofessur für Medizinische Physik und Biophysik am Gottfried Schatz Forschungszentrum

 

Universitätsprofessur für Medizinische Physik und Biophysik

am Gottfried Schatz Forschungszentrum
Lehrstuhl für Medizinische Physik und Biophysik

 

An der Medizinischen Universität Graz steht der Mensch in seiner Gesamtheit im Mittelpunkt.
Handlungsleitend für unser Tun ist es, die uns anvertrauten Menschen mit ganzem Einsatz auf
höchstem Niveau zu betreuen, zu begleiten, auszubilden und in ihrer Entwicklung zu fördern.
Wir suchen Mitarbeiter*innen, die sich mit Innovationsgeist an der Erfüllung unserer übergeordneten
Aufgabe beteiligen möchten, durch Forschung, Lehre, Lernen sowie unterstützende Administration,
die Gesundheit und das Wohlbefinden der Patient*innen zu fördern.
“Pioneering Minds – Research and Education for Patients‘ Health and Well-being” ist es, was uns
antreibt.
Werden Sie Teil eines außergewöhnlichen Teams:
UNIVERSITÄTSPROFESSUR FÜR MEDIZINISCHE PHYSIK UND
BIOPHYSIK
AM GOTTFRIED SCHATZ FORSCHUNGSZENTRUM
LEHRSTUHL FÜR MEDIZINISCHE PHYSIK UND BIOPHYSIK
Der zukünftige Lehrstuhl für Medizinische Physik und Biophysik (derzeit: Lehrstuhl für Biophysik)
und seine Einbettung in das Gottfried Schatz Forschungszentrum bieten die exzellente Basis für
die Erfüllung der vielfältigen Aufgaben in Lehre und Forschung. Der*Die Lehrstuhlinhaber*in
bearbeitet relevante wissenschaftliche Fragestellungen in enger Kooperation mit den
vorklinischen Forschungsteams und den klinischen Disziplinen der Medizinischen Universität
Graz. Der*Die für die Leitungsfunktion des Lehrstuhls vorgesehene Universitätsprofessor*in wird
mit folgenden zentralen Aufgaben betraut:
- Fachliche, didaktische und organisatorische Leitung des Lehrstuhls für Medizinische Physik und
Biophysik nach anerkannten Qualitätsmaßstäben einschließlich zeitgemäßer und effektiver
Mitarbeiter*innenführung
- Regionale, nationale und internationale Vertretung des Fachbereichs Medizinische Physik und
Biophysik, insbesondere durch international anerkannte Forschungstätigkeit
- Sicherstellung hochqualitativer Lehre für den Fachbereich Medizinische Physik und Biophysik für
die Studien Humanmedizin und Zahnmedizin (Lernzielkatalog: https://lernzielkatalogmedizin.at/subjects/biophysik/) verbunden mit dem maßgeblichen Engagement in der Abhaltung
und Weiterentwicklung universitärer Lehre mit verstärktem Fokus auf forschungs- und
anwendungsorientierte Lehre mit klinischem Bezug
- Abgestimmte Förderung von Jungforscher*innen mit gezielter Spezialförderung von
Ausnahmetalenten („Pioneering Minds“)
- Thematische Einbindung in und Erweiterung von bestehenden Forschungsaktivitäten sowie
kooperative Mitwirkung an der Weiterentwicklung des Gottfried Schatz Forschungszentrums im
Strategiekomitee und Zusammenarbeit mit den Lehrstühlen des Zentrums
- Verstärkte interdisziplinäre Kooperation innerhalb der Medizinischen Universität Graz, am
Wissenschaftsstandort Graz (zB BioTechMed-Graz), national sowie international. Aktive
Beteiligung an Innovationsprozessen mit Partner*innen aus der Wirtschaft
Für diese vielseitige Position bringen Sie folgende Qualifikationen und Kenntnisse mit:
- Abgeschlossene inländische oder gleichwertige ausländische Universitätsausbildung in
Humanmedizin und/oder wissenschaftliches Doktorat in einem naturwissenschaftlichen oder
technischen Fach mit Bezug zur Humanmedizin
- Habilitation oder gleichwertige wissenschaftliche Befähigung
- Mehrjährige einschlägige, postdoktorale Auslandserfahrung an einer Forschungsstätte
- Führungs- und Managementerfahrung an einer wissenschaftlichen Einrichtung
- Mehrjährige universitäre Lehrtätigkeit in den Fächern Medizinische Physik und/oder Biophysik
primär in Grundstudien
- Hochqualitative und kontinuierliche, wissenschaftliche Publikationstätigkeit
- Nachweis der erfolgreichen Akquise von (inter-)nationalen kompetitiv eingeworbenen
Forschungsförderungsmitteln
- Nachweisbare ausgeprägte (inter-)nationale Vernetzung
- Mehrjährige wissenschaftliche Tätigkeit in experimenteller kardiovaskulärer Elektrophysiologie
bzw. experimenteller kardiovaskulärer Biophysik, vorzugsweise hinsichtlich Gewebe- und/oder
Organfunktion
Idealerweise zählen zu ihrem Profil:
- Ausgeprägte didaktische Fähigkeiten
- Interdisziplinäre Kooperationsbereitschaft und -erfahrung
- Managementqualifikationen insbesondere im Qualitätsmanagement
- Qualifikationen in Genderkompetenz und Diversitymanagement sowie Interesse an der Integration
von Genderaspekten im Bereich der Forschung und Lehre
- Visionäre Gestaltungsmotivation
- Organisationsgeschick, Teamorientiertheit und Empathie
- Hohe kommunikative und soziale Kompetenz
Sie werden als Universitätsprofessor*in für Medizinische Physik und Biophysik unbefristet an der
Medizinischen Universität Graz angestellt und sind für die Leitung des Lehrstuhls für Medizinische
Physik und Biophysik vorgesehen.
Das Gehalt für diese Position ist Gegenstand der Berufungsverhandlung.
(Gesetzliche Information: Mindestentgelt auf Basis der Einstufung nach Kollektivvertrag für die
Arbeitnehmer*innen der Universitäten gemäß § 49 Abs. 1 KV).
Wir freuen uns über Ihre Onlinebewerbung im Berufungsportal der Medizinischen Universität Graz bis
spätestens 15.6.2022. Das Berufungsportal finden Sie unter folgendem Link:
https://This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kontakt: This email address is being protected from spambots. You need JavaScript enabled to view it.
Die Medizinische Universität strebt eine Erhöhung des Frauenanteils insbesondere in
Leitungsfunktionen an und fordert daher qualifizierte Frauen zur Bewerbung auf. Bei gleicher
Qualifikation werden Frauen vorrangig aufgenommen. Darüber hinaus sind wir bemüht, Personen
mit Behinderungen bei geeigneter Qualifikation einzustellen und freuen uns über diesbezügliche Bewerbungen

 

The Medical University of Graz takes a holistic view of the human being. We are committed to
supporting, accompanying and training the people entrusted to us and promoting their development.
We are looking for employees with an innovative spirit who would like to help us fulfill our overriding
mission of promoting the health and well-being of our patients through research, teaching, learning
and administrative support.
“Pioneering Minds—Research and Education for Patients' Health and Well-being" is the strategy and
mission that keeps us moving forward.
Become part of an extraordinary team:
UNIVERSITY PROFESSORSHIP IN MEDICAL PHYSICS AND
BIOPHYSICS
AT THE GOTTFRIED SCHATZ RESEARCH CENTER
CHAIR OF MEDICAL PHYSICS AND BIOPHYSICS
The future Division of Medical Physics and Biophysics (currently: Division of Biophysics) and its
integration in the Gottfried Schatz Research Center provide excellent support in fulfilling the
diverse teaching and research tasks. The successful candidate works on relevant scientific issues
in close cooperation with the research teams in preclinical and the clinical disciplinary areas at
the Medical University of Graz.
Core duties and responsibilities:
- Professional, educational and organisational management of the Chair of Medical Physics and
Biophysics in accordance with recognised quality standards, including contemporary and effective
staff management
- Regional, national and international representation of the Division of Medical Physics and
Biophysics, and in particular through internationally recognised research activities
- Ensuring high-quality teaching for the Division of Medical Physics and Biophysics in studies of
human medicine and dentistry (catalogue of learning objectives: https://lernzielkatalogmedizin.at/subjects/biophysik/) combined with a decisive commitment toward delivering and
further developing teaching at the university level, placing an increased emphasis on research and application-based teaching with a clinical reference
- Coordinated support for young scientists, offering directed, special support for exceptionally
talented individuals (“Pioneering Minds”)
- Thematic integration into and expansion of the existing research activities as well as cooperative
involvement in the further development of the Gottfried Schatz Research Center as a member of
the strategy committee and cooperation with other division chairs at the Center
- Support of increased interdisciplinary cooperation within the Medical University of Graz, within
Graz as a centre of science (e.g. BioTechMed-Graz), nationally and internationally. Active
participation in innovation processes with industrial partners
To fill this versatile position, you should have the following qualifications and knowledge:
- Domestic or equivalent foreign university education in human medicine and/or a scientific
doctorate in a field of the natural or technical sciences related to human medicine.
- Habilitation (venia docendi) or equivalent scientific qualification
- Several years of relevant post-doctoral experience obtained abroad at a research institution
- Leadership and management experience at a scientific institution
- Several years of university teaching experience in the subjects of medical physics and/or
biophysics, primarily at the undergraduate level
- Proof of high-quality and continuous scientific publication activity
- Proof of successful acquisition of (inter)national competitively acquired research funding.
- Proof of distinct and effective (inter)national networking
- Several years of scientific experience in the areas of experimental cardiovascular
electrophysiology or experimental cardiovascular biophysics, preferably with regard to tissue
and/or organ function.
Ideally, your profile should also include:
- Strong educational skills
- Willingness to strengthen interdisciplinary cooperation and experience with such cooperation
- Management qualifications, especially in quality management
- Qualifications in gender competence and diversity management as well as interest in the
integration of gender aspects in the field of research and teaching
- Visionary motivation to reshape
- Organisational skills, team-oriented and empathic personality
- High communicative and social competence skills
You will be employed as a University Professor for Medical Physics and Biophysics at the Medical
University of Graz for an unlimited period of time and will be responsible for acting as Chair of the
Division of Medical Physics and Biophysics.
The final salary for this position will be agreed upon during the negotiation process.
(Legal information: the minimum salary is based on the classification in the collective agreement for all university
employees (in German: Kollektivvertrag, KV) pursuant to § 49 para. 1 KV).
The Medical University of Graz warmly invites all interested candidates to submit their application
via the online application portal by no later than 15.6.2022.
You can access the online application portal at:
https://This email address is being protected from spambots. You need JavaScript enabled to view it.
For more information, contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
The Medical University is committed to increasing the proportion of women, especially in leading
positions, and thus encourages qualified women to apply. Among applicants with equal
qualifications, female applicants will be given priority. In addition, we welcome applications from
people with disabilities and appropriate qualifications and encourage the respective candidates apply.

PhD position (m/f/d) in Molecular Biophysics of Antibiotic Resistance (65% TV-L E13, 36 month).

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PhD position (m/f/d) in Molecular Biophysics of Antibiotic Resistance (65% TV-L E13, 36 month).

The Kozuch group investigates the function of (membrane) proteins that are relevant for the evolution of antimicrobial resistance. Particular attention is paid to how electrostatic interactions shape the formation of functional motifs. The methodological approach is based on a combination of vibrational spectroscopy and computer-aided simulations supplemented by the use of model membrane systems and biochemical methods. Dr. Jacek Kozuch completed his doctoral thesis in biophysical chemistry at the Technical University of Berlin, then did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at the Freie Universität Berlin.

This DFG-funded project aims to research how physical/non-covalent interactions in proteins contribute to the evolution of antibacterial resistance. By combining theoretical and experimental approaches, methods of computer-assisted vibrational spectroscopy will be developed in order to understand clinically relevant evolutionary trajectories.

Relevant publications:

https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.1c00578

https://pubs.acs.org/doi/abs/10.1021/acscentsci.1c00880

We offer:

  • the opportunity to conduct a doctorate within the stimulating, interdisciplinary and international environment of Freie Universität Berlin,
  • the entry into fascinating and biomedically relevant topics of molecular biophysics,
  • the development of modern, experimental and computer-aided vibrational spectroscopy.

Requirements and Qualifications

Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, bioinformatics or in one of the related natural sciences.

We are looking for candidates with:

Experience with molecular dynamics simulations and/or vibrational spectroscopy; Knowledge and enjoyment in coding with Python; Willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; Fun and fascination with science, especially in the field of molecular biophysics.

The area of ​​responsibility includes:

  • the independent processing of this scientific project,
  • the implementation of molecular dynamics simulations of biomolecules in particular,
  • infrared spectroscopic measurements in external electric fields (vibrational Stark spectroscopy),
  • willingness to participate in international conferences,
  • the opportunity for a doctorate is given as part of the third-party funded research project.

Selection process

Please contact Dr. Jacek Kozuch if more information is required (This email address is being protected from spambots. You need JavaScript enabled to view it. / +49 (0)30 838 64888) or visit the FU Berlin homepage: https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/wiss/20_fb-physik/PH-DFG-KO5464-4-1.html

Applications should be sent electronically until Feb. 28, 2022, indicating the reference code DFG-KO5464/4-1, (preferably as one PDF) to Dr. Jacek Kozuch: This email address is being protected from spambots. You need JavaScript enabled to view it..

POSTDOCTORAL POSITION IN PROTEIN STRUCTURAL DYNAMICS AND FOLDING USING HDX-MS

 
The Laboratory of Molecular Bacteriology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven (https://rega.kuleuven.be/bac/economou) wishes to recruit a postdoctoral fellow in the following projects: a. Protein folding and chaperone interactions. b. Structural dynamics of membrane associated/embedded channels and motors. The lab studies protein trafficking through the Sec and the Type III secretion systems (Krishnamurty 2022 CellReports; Krishnamurty 2021 Structure; Yuan 2021 JMolBiol; Portaliou 2018 EMBO J; Saio
 2014 Science 344; Gouridis 2013 Mol Cell 52; Chen 2011 Mol Cell 44; Gouridis 2009 Nature 462; Gelis 2007
 Cell 131) and disordered/flexible human proteins involved in disease and chaperoning (e.g. Bcl-2 and IP3-regulated Ca2+ channel, prolyl oligopeptidase, endophilin; Rosa 2021 CellDeathDifferentiation; Tsirigotaki 2017 SciReports). In the process we develop HDX-MS-related methods (Smit 2021 Analytical Chemistry; Claesen 2021 Analytical Chemistry). We have a very international lab environment and use multi-disciplinary approaches that combine Hydrogen Deuterium Exchange/Native/nanoLC mass spectrometries and single molecule FRET as core tools with molecular microbiology and genetics, recombinant DNA technologies, enzymology, protein chemistry, protein biophysics (including Isothermal Titration Calorimetry, Circular Dichroism, ensemble fluorescence, size exclusion chromatography coupled online to static and dynamic laser light scattering detection). All methods are applicable on available lab equipment. Our lab Waters Synapt G2 MS is equipped with a nanoAcquity UPLC and HDX capabilities. We also have direct access to two Orbitraps: a Q-exactive and an Elite. We use MassLynx, PLGS, DynamiX and in-house developed software like PyHDX.
Responsibilities

Research at postdoctoral level using HDX-MS and related techniques and flows

Profile

Successful candidates should:

·       hold a BSc/PhD in Chemistry or Biochemistry or Physics or a related degree.

·       have experience in using HDX-MS and/or native MS or other MS methods.

·       be experienced in protein purification and biochemistry.

·       have a genuine interest in research and scientific discovery and particularly in protein structural dynamics, protein interactions and folding.

·       Additional experience in biophysical methods and/or bioinformatics will be appreciated. 

·       have a good command of English.

 Offer

The position is available immediately. 

Applications ahould include: 

a) complete CV, 

b) list of scientific publications, 

c) short summary of performed research project(s),

d) detailed hands-on experience with MS instruments and 

e) names and contact details of 2-3 referees, should be sent to: Prof. Tassos Economou (This email address is being protected from spambots. You need JavaScript enabled to view it., subject: HDX_2022_LMB).

Interested?
For more information please contact Mrs. Lily Karamanou, tel.: +32 16 37 92 08, mail: This email address is being protected from spambots. You need JavaScript enabled to view it. or Prof. dr. Tassos Economou, tel.: +32 16 37 92 73, mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
You can apply for this job no later than December 15, 2022 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..

PhD Student or Postdoctoral Fellow (f/m/d)

The Max Planck Institutes for Biophysical Chemistry and Experimental Medicine in Göttingen are internationally leading research institutes of exceptional scientific breadth, which will merge in 2022 to become the largest institute of the Max Planck Society. The new institute will comprise more than 40 research groups and employ around 1,000 people from over 50 nations.
The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as

PhD Student or Postdoctoral Fellow (f/m/d)

for molecular dynamics simulations based projects in the areas

• Ribosomal Translation: Molecular Mechanisms and Antibiotics
• Statistical Mechanics and Function of Intrinsically Disordered Proteins
• Optimal Free Energy and Entropy Calculations
• Markovian Free Energy Models of F-ATP Synthase Function
• The Dynasome: Classifying protein motions

The successful candidate for either position has a keen interest and strong skills in computational biomolecular physics, statistical mechanics, and scientific computing, and a strong interest in interdisciplinary research and collaboration with experimental groups.
PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field.
PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.
Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible. The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German!
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via E-Mail as single PDF file. Applications will be reviewed on a rolling basis until the position is filled.
Submit your application to:
This email address is being protected from spambots. You need JavaScript enabled to view it.

Max Planck Institute for Biophysical Chemistry Department „Theoretical and Computational Biophysics“
Prof. Dr. Helmut Grubmüller
Am Fassberg 11
37077 Göttingen Germany
Web: www.mpibpc.mpg.de/grubmueller Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.

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