Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function. Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.

We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it. publications:
Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857
Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174

Further information: www.biophysik.uni-konstanz.de
Distributed: 1.12.2020

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 46.000 students, 7.300 employees and a turnover of SEK 7.3 billion.
The Department of Chemistry - Ångström conducts research and education in the chemistry field. The department has more than 250 employees and has a turnover just over 250 million SEK. At the department's six programs, we conduct very successful research of a high international standard. We have a large number of externally funded research projects, often with international cooperation and we see continued good growth in our subject area. The department has education assignments in engineering and civil engineering programs and master's programs. More information is available on our website.
In the research program Physical Chemistry we conduct fundamental and goal oriented research in colloid and surface science, photochemistry and chemical dynamics, laser spectroscopy, as well as molecular and mesoscopic systems for solar energy conversion.
We are now looking for a highly motivated postdoctoral researcher to join one of our research groups in colloid and surface science.

Description of research project:
The group conducts research focused on fundamental studies and bioanalytical/pharmaceutical applications of soft surfaces and nanoparticles formed by polar lipids. The projects are as a rule inspired by issues of biological or medical/pharmaceutical relevance. Ongoing studies include investigations to reveal mechanisms and factors that govern or influence stability and permeability of lipid membranes. Projects of more applied character aim at the development of liposomes and related lipid-based nanoparticles for formulation and delivery of different classes of anticancer agents. The research is often carried out in national or international collaboration with partners within the fields of pharmacy or medicine
Work duties:
The objective of the postdoctoral project, funded by the Swedish Cancer Society, is to explore the potential of a novel type of lipid-based nanocarriers for tumour targeted delivery of chemotherapeutics, anticancer peptides, and therapeutic radionuclides. Specific tasks for the postdoc will include development of methods for production and drug loading of the nanocarriers, as well as studies of their interaction with, and cytotoxic effect on, tumour cells. The tasks may also include pharmacokinetic investigations and studies focused on biodistribution of the carriers and their drug load.
The main duties involved in a post-doctoral posistion is to conduct research. Teaching may also be included, but up to no more than 20% of working hours.
Requirements:
For employment as postdoc, the applicant should have a PhD exam or an international equivalent within the field of chemistry, biology, pharmacy, medicine or technology, or other for the position relevant fields, within a maximum of three (3) years before the final application date. During certain circumstances, an earlier PhD can be acceptable. Certain circumstances include leave due to illness, parental leave, in trade unions, etc.
The assessment of applications is based primarily on the applicant's ability to conduct independent research based on scientific skill. Greater importance is attached to the quality of individual scientific work, than to the amount of publications.
Documented experience of in vitro cell studies is required. The applicant must have good communication skills and be proficient in both oral and written English. Consideration will also be given to good collaborative skills, drive and independence, and how the applicant’s experience and skills complement and strengthen ongoing research within the department, and how they stand to contribute to its future development.
Additional requirements: Documented experience of in vivo animal studies and work with radiation- based techniques is beneficial. Previous experience of research concerning liposomes or related nanocarriers is desirable.
Salary: Individual pay.
Starting date: 2021-02-01 Type of employment: Temporary position for two years. Scope of employment: 100 % For further information about the position please contact: Katarina Edwards (This email address is being protected from spambots. You need JavaScript enabled to view it.) or Lars Gedda (This email address is being protected from spambots. You need JavaScript enabled to view it.).

Please submit your application by January 4 2021, UFV-PA 2020/4576. Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus.
You are also welcome to contact International Faculty and Staff Services at This email address is being protected from spambots. You need JavaScript enabled to view it..
Please do not send offers of recruitment or advertising services. Submit your application through Uppsala University's recruitment system. (https://www.uu.se/en/about-uu/joinus/jobs/) 

Topic
Genetically encodable fluorescence markers for imaging of specific RNA molecules in live  cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab,  IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell super‐ resolution localization microscopy  applications. 

Candidate
We are looking for an excellent, highly motivated person with a degree in (bio)physics,  physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis. 

Contact
Prof. Dr. Gerd Ulrich Nienhaus (This email address is being protected from spambots. You need JavaScript enabled to view it.) Institute of Applied Physics, KIT, 76131 Karlsruhe

References
Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke. 
SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562  (2019)

Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün, 
F., Nienhaus, K., Nienhaus,  G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with  fast exchange kinetics.  Nature Biotechnol., in press. 

http://www.aph.kit.edu/nienhaus/

Our Profile
The research activities of the AG Biophysik aim to establish a fundamental, physics-based understanding of the function of bio-macromolecular systems. In this respect proteins and (protein based) macromolecular complexes, also within in their cellular context, are of particular interest for our research topics. The experimental techniques used are confocal fluorescence spectroscopy and single molecule wide-field microscopy. Thereby fluorescence correlation spectroscopy (FCS), simultaneous multi-color detection, and Förster resonance energy transfer (FRET) are employed in our research projects. We offer the possibilities to work with state-of-the-art equipment at the interface between physics and molecular biology in a highly motivated group and an international and interdisciplinary working environment at the RWTH Aachen University and at the Forschungszentrum Jülich.

Your Profile
o A higher Degree (PhD) in Physics, Chemistry or Biochemistry and a Doctorate in a related field o Extensive knowledge of high resolution fluorescence microscopy and spectroscopy
o Comprehensive experience in conducting research projects in structural biology by using fluorescence based single molecule techniques.
o The ability to communicate and work effectively in an interdisciplinary an international team
o A structured and systematic approach to problem solving

Your Duties and Responsibilities
We are looking for an excellent and highly motivated postdoc candidate for a DFG funded research project «Cotranslational mechanisms of protein folding studied on the single molecule level» which will be conducted in a close collaboration with the Institut für biologische Informationsprozesse IBI-6 at the Forschungszentrum Jülich. You will be part of a team using state-of-the-art equipment (TIRF microscope for simultaneous dual color imaging, confocal microscope with pulsed excitation and multi-channel detection) which investigates structural and dynamical properties of proteins and protein complexes. This includes to application of nano-apertures like zero mode waveguides (ZMWs) to study protein ligand interactions at physiological relevant concentrations on single molecule level. The results of your research are expected to be published in international peer reviewed journals.

What We Offer
The successful candidate will be employed under a regular employment contract. Research Assistant (f/m/d) - RWTH AACHEN UNIVERSITY -
English https://www.rwth-aachen.de/cms/root/Die-RWTH/Arbeiten-an-der-... 
The position is to be filled at the earliest possible date and to 2 years. This is a full-time position. Applicants must have a doctorate/Ph.D. or equivalent. The salary corresponds to pay grade EG 13 TV-L of the German public service salary scale (TV-L). RWTH is a certified family-friendly University. We support our employees in maintaining a good work-life balance with a wide range of health, advising, and prevention services, for example university sports. We also offer a comprehensive continuing education scheme and a public transportation ticket available at a significantly reduced price. RWTH is an equal opportunities employer. We therefore welcome and encourage applications from all suitably qualified candidates, particularly from groups that are underrepresented at the University. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of national or ethnic origin, sex, sexual orientation, gender identity, religion, disability or age. RWTH is strongly committed to encouraging women in their careers. Female applicants are given preference if they are equally suitable, competent, and professionally qualified, unless a fellow candidate is favored for a specific reason. As RWTH is committed to equality of opportunity, we ask you not to include a photo in your application.
You can find information on the personal data we collect from applicants in accordance with Articles 13 and 14 of the European Union's General Data Protection Regulation (GDPR) at http://www.rwth-aachen.de/dsgvoinformation-bewerbung
Application Number: 32935
Application deadline: 15.02.2021
Mailing Address: Prof. Dr. Jörg Fitter I. Physikalisches Institut (IA), AG Biophysik RWTH Aachen University 52056 Aachen GERMANY Email This email address is being protected from spambots. You need JavaScript enabled to view it. Applicants are invited to submit their applications via email. For data protection reasons, however, we recommend sending applications via mail.

Further Information
http://www.institut-1a.physik.rwth-aachen.de/cms/INSTITUT-1A/Forschung/~iecj/Biophysik/ [http://www.institut-1a.physik.rwth-aachen.de/cms/INSTITUT-1A/Forschung/~iecj/Biophysik/]

Contact Name Prof. Dr. Jörg Fitter Telephone +49 241 80 27209 E-Mail Send Email [mailto:This email address is being protected from spambots. You need JavaScript enabled to view it.] Institution I. Physikalisches Institut (IA), AG Biophysik