PhD Student or Postdoc (f/m/d) for the project Theory and Algorithms for Structure Determination from Single Molecule X-Ray Scattering Images

The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.

The Department of Theoretical and Computational Biophysics headed by Helmut Grubmüller is inviting applications for a

PhD Student or Postdoc (f/m/d)

for the project

Theory and Algorithms for Structure Determination

from Single Molecule X-Ray Scattering Images

Project description

Single molecule X-ray scattering experiments with free electron lasers offer a new route to the structure determination of biomolecules. In addition, they hold the potential to not only determine the molecular structure, but also its dynamics. However, computing the structure from such data poses a highly complex mathematical problem, and new theoretical methods and algorithms are required. The main goal of this particular research project is to develop Bayesian methods to determine molecular structures and dynamics. It also offers the opportunity to work with data from the European XFEL facility at DESY and, depending on the interests of the applicant, many possible connections to other research areas like, for example, molecular dynamics or machine learning.

Project website:

Your profile

  • Strong skills in theoretical and computational physics or probability theory
  • Great interest in interdisciplinary research and collaboration with experimental groups

PhD students hold (or expect to complete soon) a Masters or equivalent degree in physics, mathematics or any related field; correspondingly, postdocs hold a PhD or equivalent degree in the above mentioned fields.

What we offer

  • State of the art on-site compute facilities
  • Competitive research in an inspiring, world-class environment
  • A wide range of offers to help you balance work and family life: on-campus kindergarten places including vacation care, parent-child offices, etc.
  • Further training opportunities and free in-house language courses

The group language is English, so no German language skills are required – but it is a great opportunity for you to learn German!

Position details

PhD students will have the opportunity to participate in one of several available PhD programs, with three years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.

Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and, therefore, encourages applications from such qualified individuals. The Max Planck Society strives for diversity and gender equality and welcomes applications from all backgrounds.


Applications will be reviewed on a rolling basis until the position is filled.

Please submit your application including a cover letter (explaining background and motivation), a CV and transcripts (translated to English or German, if applicable) preferably via e-mail and as a single PDF file to:

This email address is being protected from spambots. You need JavaScript enabled to view it.

Max Planck Institute for Multidisciplinary Sciences

Department of Theoretical and Computational Biophysics

Hon.-Prof. Dr. Helmut Grubmüller

Am Faßberg 11

37077 Göttingen




Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.

Wissenschaftliche/n Mitarbeiter/in (m/w/d) für den Schwerpunkt Lehre an der PMU Salzburg

Am Nürnberger Standort der Paracelsus Medizinischen Universität (PMU) aus Salzburg wird in Kooperation mit dem Klinikum Nürnberg seit 2014 das Studium der Humanmedizin angeboten. Für die zuständige Tochtergesellschaft, die Klinikum Medical School GmbH, suchen wir zum nächstmöglichen Zeitpunkt zur Verstärkung des Universitätsinstituts für Physiologie, Pathophysiologie und Biophysik am Standort Nürnberg eine/n in Lehre und Forschung engagierte/n

Wissenschaftliche/n Mitarbeiter/in (m/w/d)
für den Schwerpunkt Lehre


in Teilzeit (20 Wochenstunden)

Das CPPB - Centrum für Physiologie, Pathophysiologie und Biophysik - der Paracelsus Medizinischen Universität vertritt an seinen beiden Standorten in Salzburg und Nürnberg die Fächer Physiologie und Pathophysiologie in Lehre und Forschung. Das Institut am Standort Nürnberg steht unter der Leitung von Herrn Professor Dr. Dr. Boris Musset. In der Lehre wird ab August 2023 das Curriculum des Bachelor- / Masterstudiums Humanmedizin der Paracelsus Medizinischen Universität vermittelt.

Ihr Profil:

  • Ein abgeschlossenes Hochschulstudium der Medizin oder der Naturwissenschaften
  • Erfahrung in der Lehre und Ausbildung von Studierenden ist wünschenswert
  • Bereitschaft zur kontinuierlichen Weiterentwicklung der didaktischen Fähigkeiten
  • Eine Promotion ist wünschenswert
  • Gute Deutsch- und Englischkenntnisse sind erforderlich
  • Kommunikationsstärke und Teamfähigkeit

Wir bieten:

  • Eine interessante Tätigkeit als Lehrkraft an unserem Universitätsinstitut, insbesondere durch die eigenständige Vorbereitung und Betreuung von Vorlesungen, Praktika und Seminaren
  • Die Mitarbeit in einem engagierten, dynamischen, internationalen Team in einem wachsenden Institut
  • Die Chance, die universitäre Lehre und Forschung mitzugestalten
  • Die Möglichkeit für eigenständige Forschung in der Ausrichtung Life Science und/oder Biophysik und/oder Molecular Dynamics
  • Flexible Arbeitszeiten nach Absprache

Die Klinikum Nürnberg Medical School GmbH strebt eine Erhöhung des Frauenanteils an und lädt deshalb qualifizierte Frauen ausdrücklich zur Bewerbung ein. Bewerberinnen, die gleich geeignet sind wie der bestgeeignete Mitbewerber, werden vorrangig berücksichtigt.

Die Stelle ist ab 01.06.2023 zu besetzen und vorläufig auf ein Jahr befristet mit Option auf Entfristung. Bitte senden Sie Ihre aussagekräftige Bewerbung mit Angabe Ihrer Verfügbarkeit und Ihrer Gehaltsvorstellung an:

Klinikum Nürnberg Medical School GmbH
Tel. 0911 398-6765

PhD Project on Interaction of Rhodopsin and Cryptochrome as the Basis for Opto-Magnetic sensing in Birds

Magnetosensing is mandatory for seasonal long distant flights of birds and butterflies from north to south
and back and to find the home places of previous years. During the past 40 years strong evidence has
been collected that for magnetic orientation blue light sensitive Cryptochromes within the retina of the
eyes are responsible.
However, since birds are able to navigate at very low light intensities during the night an interaction of the
abundant rhodopsins with the only scarcely expressed Cryptochromes has been suggested.
In the open project unusual rhodopsins of birds and butterflies and their interaction with Cryptochromes
will be studied and characterized in detail in order to understand animal magnetic sensing. Behavioral
studies will be carried out in collaboration with behavioral zoologists.
Magnetosensing, Photobiology, unusual rhodopsins, flavin-based photoreceptors, UV-Vis and infrared
spectroscopy, EPR, ultra-fast spectroscopy.
Entry requirements
The applicant needs a MSc. degree (or equivalent) in biochemistry, biophysics, biology or related fields.
Basic skills in molecular biology are mandatory. The applicant should be prepared to work in a highly
interdisciplinary team with strong international collaborations.
Humboldt Universität zu Berlin, Institute of Biology, Experimental Biophysics, Invalidenstraße 42, D-10115
Between August and December 2023
Four years of funding (3+1, three years with the possibility to extend for one year)

2023-HFA-Advertised-position_Hegemann.pdf (

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’


PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

As part of the Cluster of Excellence ‘Unifying Systems in Catalysis’ (UniSysCat), the Horch research group ‘Ultrafast Dynamics in Catalysis’ aims to understand complex catalytic systems and superordinate reaction networks by using an integrated approach of advanced spectroscopic and theoretical methods. In particular, we are interested in metalloenzymes – huge metal-containing proteins that catalyse, e.g., the conversion of small molecules like H2 and CO2.

More details about the Horch research group and UniSysCat, can be found here:

Project Description

To establish a “greener” chemistry based on living cells, we envisage the design of a cellular system that uses waste material and unlimited sun light for sustainable hydrogen production. Developing such a system requires a detailed understanding of all involved processes on the molecular and cellular level. Together with multiple partners, the successful candidate will develop a multichannel in vivo spectroscopy approach to target the involved biological macromolecules, relevant cytoplasmic factors, and the interplay of these two types of cellular key determinants. Focusing on the hydrogen-producing enzyme, a [NiFe] hydrogenase, this strategy will expand previously established in vivo spectroscopic strategies by introducing ultrafast and multidimensional infrared techniques that yield details insights into structure, dynamics, and environmental interactions. In total, this approach will provide a guideline for the rational design of cellular catalytic systems.

Relevant Publications

Field of Work

- Ultrafast nonlinear infrared spectroscopic experiments (2D-IR and IR-IR pump-probe)

- Execution of such experiments at international research facilities

- Analysis and interpretation of spectroscopic data

- Interdisciplinary cooperation with other members of the overarching team project

- Manipulation and handling of delicate biological samples supplied by collaboration partners

- If beneficial, calculation of infrared spectroscopic observables by quantum chemical methods

- Writing of scientific articles for publication in international peer-reviewed journals

- Presentation of research results at international scientific conferences

We Offer

We offer a position in an exciting and challenging project with the opportunity to obtain a PhD. The project will be pursued in a dynamic, international, and cooperative team of scientists from different fields of research. The project is also part of UniSysCat, which provides the opportunity to engage in interdisciplinary collaborations and build scientific networks. As a first-class location for science and a vibrant global city, Berlin offers an ideal framework.


Master’s degree (or equivalent) in the field of physics, physical chemistry, biophysics or similar

Desirable Qualification

Expertise and experience in the following areas is desirable, but knowledge in all them of them is not mandatory. Applications from candidates that are willing to learn about the listed aspects are welcome

- Excellent university degree

- Experience with infrared spectroscopy or vibrational spectroscopy in general

- Experience with ultrafast nonlinear spectroscopy and data analysis

- Experience with (pulsed) laser sources and (nonlinear) optics

- Experience with quantum chemical calculations

- Experience with the handling of biological and/or oxygen-sensitive samples 

- Knowledge in biological, inorganic, and/or photo chemistry

- Programming skills, preferably in Python

- Ability to work independently and as part of an interdisciplinary team

- Creativity, enthusiasm, and a genuine interest in the advertised project

- Fluency in English (spoken and written)


Starting Date

As soon as possible

Application Deadline

13 March 2023. Applications sent after the deadline will be considered until the position is filled.


TV-L E13 (67 %) until 31 December 2025, funding by the DFG via UniSysCat, funding extension from other sources is possible

Selection Process

Please send your documents and requests to Dr. Marius Horch (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Further details can be found here:

Doctoral & Postdoctoral Positions in Computational Membrane Biophysics in Erlangen


Doctoral & Postdoctoral Positions in Computational Membrane Biophysics in Erlangen

Applications are invited for PhD positions/Postdoc/Senior Postdoc in our lab for theoretical and computational membrane biophysics at the Friedrich-Alexander University of Erlangen-Nürnberg, Germany.

Plasma membranes and in general biomembranes establish and maintain differences in composition between the cell or organelle interior and exterior. Biomembranes are the site for cell-cell recognition, they allow active and passive transport of material into and out of the cell, and they harbour proteins as initiators of signal transduction pathways.

Projects address the physico-chemical driving forces for the establishment of membrane domains within the immune cell plasma membrane, and their role for sensing of external signals by immune receptors and signal transduction, as well as membrane remodeling. The aim is to shed light on the cooperative action of proteins and lipids in shaping biomembrane structure.

Central questions for our research are

  • How are external signals sensed by immune cells, how do lipids contribute to signal transfer across the cell membrane, and how do lipids modulate immune cell activation?
  • What is the role of plasma membrane domains in immune cell activation?
  • Can we modulate or control immune cell function by cell membrane composition?

and more general

  • What are the physical driving forces for membrane domain formation?
  • How is domain formation linked to plasma membrane asymmetry?
  • How are plasma membrane asymmetry and biological membrane processes interlinked?

Applicants for doctoral positions:

Candidates should preferably hold a master degree in bio-/physics, theoretical/computational chemistry, life sciences or similar and a strong interest in interdisciplinary projects and collaborations to medical/immunology groups.


Postdoc applicants:

The successful applicant has a keen interest and strong skills in methods from statistical and computational physics, in particular atomistic and coarse-grained molecular dynamics simulations. The project involves close collaboration with immunology groups. The Postdoc will have the opportunity to participate in a research cluster studying the structure and function of immune domains.

Other requirements:

High level of English and good communication skills; effective team working.

Erlangen is a center for immunobiology with more than 70 groups focusing on immunological topics. In addition, since 2021, the University of Erlangen hosts a National High Performance Computing Center ( with a focus on atomistic simulations.

Interested candidates should send one pdf document containing a cover letter, CV, and certificates to

Prof. Dr. Rainer Böckmann

Computational Biology

Staudtstr. 5, 91058 Erlangen, Germany

This email address is being protected from spambots. You need JavaScript enabled to view it..