Postdoc - Molecular Simulation of SLC17 transporters

The Institute for Advanced Simulations - Computational Biomedicine (INM-9) at the Jülich Research Center uses and develops high performance computing-based multiscale simulations to investigate key molecular events for neuronal function and dysfunction. For this purpose, we work closely with the subinstitute IAS-5. Within the the DFG Research Group “Functional Dynamics of ion channels and transporters - DynIon” (https://www.uniklinikum-jena.de/dynion/en/), we are currently searching for qualified candidates with solid background in molecular dynamics, free energy calculations and statistical mechanics applied to biological systems.

Your Job:

• Investigate the molecular mechanism of proton transfer/sensitivity and substrate recognition in vesicular glutamate transporters and their bacterial homologs

• Performing multiscale molecular dynamics simulations and employing enhanced sampling methods like metadynamics

• Submission of computational projects in order to obtain the required computational resources • Contributions to workshops and training activities

• Contribute to an international research project, with a network of scientists across all over Europe

Your Profile:

• Completed study (Master) in computational chemistry, biochemistry, physics or related fields

• PhD degree in the above-mentioned fields • Demonstrated scientific track record (publications, conference participations)

• Expertise in force field-based MD simulations and Quantum Mechanics / MolecularMechanics • Experience with Linux-based systems and (preferred) high performance computing

• Ability to work independently as well as collaboratively in an international, interdisciplinary team • Very good communication and organizational skills

• Fluency in English language in written and spoken form

Our Offer:

We work on the very latest issues that impact our society and are offering you the chance to actively help in shaping the change! We support you in your work with:

• Outstanding research and computing infrastructures in one of Europe’s largest supercomputing facilities

• Further development of own scientific profile through a strong international network

• Participation in national and international conferences and workshops

• Opportunities of being part of an international scientific community

• Comprehensive training courses and individual opportunities for personal and professional further development

• Extensive company health management • Ideal conditions for balancing work and private life, as well as a family-friendly corporate policy

• Full-time position with the option of slightly reduced working hours and 30 days of annual leave

• Targeted services for international employees, e.g. through our International Advisory Service

We offer you an exciting and varied role in an international and interdisciplinary working environment. The position is initially for a fixed term of 2 years. Salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD). Depending on the applicant`s qualifications and the precise nature of the tasks, salary grade 13 TVöD-Bund. Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations. We also welcome applications from disabled persons.

Please find the whole advert here 

Scientific Project Manager & Science Writer

The Biophysics group of Professor Sandro Keller at the Institute of Molecular Biosciences (IMB) of the University Graz, Austria is looking for a

Scientific Project Manager & Science Writer

(preferably full-time employment according to FWF standard salary for postdocs; initially fixed term for two years with possible extension; position to be filled as soon as possible)

We are looking for a new team member with a keen interest and a strong track record in communicating research results. In your role as Scientific Project Manager & Science Writer, you will be responsible for coordinating research projects, visualising results, and writing manuscripts in close cooperation with laboratory researchers at all career stages. You will work in a dynamic, inspiring, and interdisciplinary environment amongst enthusiastic scientists dedicated to elucidating the molecular details of how membrane proteins function in the complex milieu of a lipid membrane. You will support our research projects by providing strategic input and feedback and by assisting with the presentation and communication of our latest scientific findings.

Your responsibilities

·     Science writing for progress reports, grant applications, and peer-reviewed publications
·     Visualising research results and models for written publications and oral presentations
·     Setting up and maintaining a website and contributing to science communication
·     Coordinating and managing research projects (mostly funded by third parties)
·     Identifying grant opportunities and possibilities for collaboration
·     Attending and contributing to group and collaboration meetings
·     Participating in third-mission tasks and public relations

Your profile

·     Doctoral degree or equivalent in the life sciences or a related scientific field
·     Excellent writing skills as required for scientific publications and grant applications
·     Very good written and spoken English language skills, at least good command of German
·     Facility with computer programs for visualising and presenting research results and models
·     Ability to communicate effectively with colleagues, collaborators, and other scientists
·     Experience in science management and communication (e.g., public relations, social media)
·     Self-driven, independent, and responsible way of working

Our offer

The minimum salary corresponds to the FWF standard salary for postdocs; the actual salary may be higher if there are previous employment periods eligible for inclusion. In case of success, the initial two-year contract will be extended. We offer an exciting job with a lot of responsibility and variety. You can expect an enjoyable work atmosphere, flexible work hours, and numerous possibilities for further education and personal development. We welcome applications from persons with disabilities who meet the requirements of the advertised position.

Your application

Your application should consist of a single PDF file containing (1) a motivation letter of no more than two pages, (2) a CV including a list of publications, and (3) the names and contact details of at least two individuals who can provide reference attesting to your professional abilities and qualifications. Please e-mail your application before 15th May 2021 to This email address is being protected from spambots. You need JavaScript enabled to view it..

Masterarbeit (M.Sc., M.Ing.) "Numerische Simulationen für additive Fertigungsverfahren in der pharmazeutischen Technologie"

Im Rahmen eines Kooperationsprojekts bietet die Abteilung für Pharmazeutische Technologie und Biopharmazie der Christian-Albrechts-Universität zu Kiel ab sofort (Sommersemester 2021) eine Masterarbeit (M.Sc., M.Ing.) an im Bereich

Numerische Simulationen für additive Fertigungsverfahren in der pharmazeutischen Technologie

Während additive Fertigungsverfahren zur Herstellung medizinischer Geräte umfassend erprobt sind, erfordert deren Nutzung zur Entwicklung wirkstoffhaltiger Darreichungsformen weitere Forschungsanstrengungen. Moderne Technologien ermöglichen die Produktion von komplexen Strukturen mit hoher Auflösung unter Verwendung neuartiger Materialien. Dieser Fortschritt offenbart für die Entwicklung von Arzneimitteln zur Inhalation vielfältige, neuartige Möglichkeiten. Um ein umfassenderes Verständnis zu Einflussfaktoren und Wechselwirkungen aufzubauen und additive Fertigungstechniken mit klassischen Pharma- und Verfahrenstechniken zu verknüpfen, werden numerische Simulationen eingesetzt.

Fragestellungen der Masterarbeit:

- Evaluierung des Verhaltens partikulärer Strukturen mithilfe von Simulationsmodellen in verschiedenen Inhalationsfragestellungen (Partikelwechselwirkungen, Partikelbewegung etc.)

- Analyse und Weiterentwicklung bestehender Simulationsmodelle (Rocky DEM)

- Integration von in-silico Parametern in additive Fertigungsprozesse

Ihr Profil:

- Student*in im Bereich Ingenieurwesen, Informatik oder in vergleichbaren naturwissenschaftlichen Studiengängen wie z.B. Life Science, Biotechnologie, Pharmazie

- Erste Erfahrungen mit numerischer Simulation und entsprechender Software

- Interesse an mathematischen Zusammenhängen und interdisziplinärer Teamarbeit

- Kenntnisse in einer der gängigen CAD-Software

- Gute Englischkenntnisse in Wort und Schrift

Im Rahmen dieser Masterarbeit arbeiten Sie an Grundlagenforschung in einem multidisziplinären und internationalen Umfeld. Sie erhalten Einblicke sowohl in ein großes Pharmaunternehmen als auch in die Forschungsaktivitäten der Pharmazie. Die Schnittstellen unterschiedlicher, moderner Technologien und deren Integration in pharmazeutische Prozesse zur Entwicklung und Herstellung von Arzneimitteln steht im Fokus Ihrer Masterarbeit. I Christian-Albrechts-Universität zu Kiel, Abteilung für Pharmazeutische Technologie und Biopharmazie, Grasweg 9a, 24118 Kiel, Germany

Bitte bewerben Sie sich direkt bei Prof. Dr. Regina Scherließ (This email address is being protected from spambots. You need JavaScript enabled to view it.) Fragen zu dieser Position beantwortet gerne: Simon Bock, This email address is being protected from spambots. You need JavaScript enabled to view it..d

Full Professorship (W3) IN MOLECULAR BIOLOGY with a focus on “Engineering of Molecular Systems”

Full Professorship (W3)
IN MOLECULAR BIOLOGY (F/M/D) with a focus on “Engineering of Molecular Systems”

The ZENTRUM FÜR MOLEKULARE BIOLOGIE (ZMBH) at Heidelberg University (Germany) is an internationally recognized research center for fundamental research in molecular and cell biology located in one of the largest life sciences campuses in Europe.

The successful candidate will contribute to the research activities at the ZMBH in molecular and cellular biology. More specifically, this professorship should have a research focus on Engineering of Molecular Systems and investigate topics such as “macromolecules of life”, “engineering of proteins and cells”, or “synthetic genomes and cell systems” at the interface between biosciences and engineering.

In 2024/2025, the holder of this position will have the opportunity to move into a new building (Heidelberg 4 Life) that expands the ZMBH and is aimed at facilitating collaborations with the nearby Max Planck Institute for Medical Research. Applicants should have outstanding research and publication records corresponding to their career stage. Active participation in teaching activities on Bachelor, Master and PhD student levels is expected. The position includes 100 % salary support and a research support budget commensurate with the W-3 level.

The ZMBH houses 15 independent research groups. We offer an excellent international research environment, which is further complemented by numerous University institutes and research centers and the Flagship Initiative “Engineering Molecular Systems”. There are several in-house scientific core facilities, i.e. protein analytics including mass spectrometry, advanced light microscopy, flow cytometry; more over mechanical and electrical workshops as well as centralized administrative services are available. Nearby facilities on campus offer additional services (https://www.cellnetworks.uni-heidelberg.de/cctp/). Our Alliance with the German Cancer Research Center (DKFZ-ZMBH Alliance) provides scientific interactions and access to central facilities and scientific infrastructure of the DKFZ.

More information on the research and teaching programs as well as on the scientific facilities can be found on our website (http://www.zmbh.uni-heidelberg.de).

Prerequisites for employment are a University degree and a lecturer qualification (habilitation) or a successfully evaluated junior professorship or equivalent qualifications (in accordance with Article 47, § 2 of the Higher Education Law of the Federal State of Baden-Württemberg). Please refer to further requirements according to § 47 and § 48(2) Higher Education Law (LHG) of the Federal State of Baden-Württemberg.

The application package should include a curriculum vitae, a list of publications, a list of current research support, a summary of teaching experience, a research summary, an outline of future research interests, and a list of references including contact information. Applications should be sent no later than April 21, 2021by e-mail to Prof. Dr. E. Schiebel, Director of the ZMBHThis email address is being protected from spambots. You need JavaScript enabled to view it.

Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Disabled persons will be given preference if they are equally qualified.
Information on the application process and the collection of personal data is available at:
http://www.uni-heidelberg.de/stellenmarkt

Please find further information here Full Professorship (W3) IN MOLECULAR BIOLOGY with a focus on (nature.com) 

PhD Position in Experimental Molecular Biophysics

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a homebuilt IR spectrometer with a laser-excited temperature-jump will be used to monitor submillisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately.
We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.
The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available. Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it.

Related publications:
Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534
Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J
Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IRspectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199

Further information: www.biophysik.uni-konstanz.de

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