Several PhD positions available at the University of Göttingen

We have several open PhD positions in biological physics. If you have a Master's degree in physics, physical chemistry, biotechnology or a related field and interest (previous experience is also appreciated) in one or more of the following fields

  • biophysics (cells and proteins)
  • microscopy
  • x-ray imaging and scattering
  • microfluidics

please visit our website (www.uni-goettingen.de/koesterlab) for more information on our work and contact us directly: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Possible dissertation topics are:

  • Mechanics of cytoskeletal filaments (microtubules, actin filaments, intermediate filaments)
  • Interactions between synaptic vesicles and the cytoskeleton
  • Force generation in cardiomyocytes
  • X-ray imaging of biological cells

We welcome new group members as soon as possible!

PhD Position in Experimental Molecular Biophysics

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a homebuilt IR spectrometer with a laser-excited temperature-jump will be used to monitor submillisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately.
We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.
The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available. Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Related publications:
Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534
Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J
Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IRspectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199

Further information: www.biophysik.uni-konstanz.de

PhD Student or Postdoctoral Fellow (f/m/d)

The Max Planck Institutes for Biophysical Chemistry and Experimental Medicine in Göttingen are internationally leading research institutes of exceptional scientific breadth, which will merge in 2022 to become the largest institute of the Max Planck Society. The new institute will comprise more than 40 research groups and employ around 1,000 people from over 50 nations.
The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as

PhD Student or Postdoctoral Fellow (f/m/d)

for molecular dynamics simulations based projects in the areas

• Ribosomal Translation: Molecular Mechanisms and Antibiotics
• Statistical Mechanics and Function of Intrinsically Disordered Proteins
• Optimal Free Energy and Entropy Calculations
• Markovian Free Energy Models of F-ATP Synthase Function
• The Dynasome: Classifying protein motions

The successful candidate for either position has a keen interest and strong skills in computational biomolecular physics, statistical mechanics, and scientific computing, and a strong interest in interdisciplinary research and collaboration with experimental groups.
PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field.
PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.
Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible. The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German!
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via E-Mail as single PDF file. Applications will be reviewed on a rolling basis until the position is filled.
Submit your application to:
Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Max Planck Institute for Biophysical Chemistry Department „Theoretical and Computational Biophysics“
Prof. Dr. Helmut Grubmüller
Am Fassberg 11
37077 Göttingen Germany
Web: www.mpibpc.mpg.de/grubmueller Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.

PhD Position in Biophysical Chemistry

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function. Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.

We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! publications:
Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857
Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174

Further information: www.biophysik.uni-konstanz.de
Distributed: 1.12.2020

PhD Student or Postdoc (f/m/d) (Code number 18-21)

Max-Planck-Institut für biophysikalische Chemie Göttingen
The Max Planck Institute for Biophysical Chemistry is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society.
The research group of Computational Biomolecular Dynamics (Prof. Dr. Bert de Groot) invites applications for a position as
PhD Student or Postdoc (f/m/d) (Code number 18-21)
for the following projects
         • Interactions of focused ultrasounds with lipid membranes and ion channels
         • Pharmacological regulation of potassium channels
         • Combined computational alchemy and deep learning for:
                      o ligand design and optimisation for drug development
                      o mutation scans in protein design and drug resistance

The successful candidate for either position has a keen interest and strong skills in computational molecular physics, structural biology, statistical mechanics, and scientific computing, and a strong interest in interdisciplinary research and collaboration with experimental groups.
PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field.
PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.
Payment and benefits are based on the TVöD guidelines. The starting date is flexible.
The group language is English. For those who are interested, the institute offers free German courses.
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.
Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!
Max Planck Institute for Biophysical Chemistry Research Group „Computational Biomolecular Dynamics“ Prof. Dr. Bert de Groot Am Fassberg 11 37077 Göttingen Germany
Web: https://www.mpibpc.mpg.de/degroot Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.

PhD Position in Super-resolution RNA Imaging

Topic
Genetically encodable fluorescence markers for imaging of specific RNA molecules in live  cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab,  IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell super‐ resolution localization microscopy  applications. 

Candidate
We are looking for an excellent, highly motivated person with a degree in (bio)physics,  physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis. 

Contact
Prof. Dr. Gerd Ulrich Nienhaus (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!) Institute of Applied Physics, KIT, 76131 Karlsruhe

References
Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke. 
SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562  (2019)

Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün, 
F., Nienhaus, K., Nienhaus,  G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with  fast exchange kinetics.  Nature Biotechnol., in press. 

http://www.aph.kit.edu/nienhaus/

PhD Student or Postdoc (f/m/d) (Code number 19-21)

Max-Planck-Institut für biophysikalische Chemie Göttingen
The Max Planck Institute for Biophysical Chemistry is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society.
The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as
PhD Student or Postdoc (f/m/d) (Code number 19-21) for the project Theory and Algorithms for Structure Determination from Ultrafast Single Molecule X-FEL Diffraction and Fluctuation Correlation X-Ray Scattering Experiments
The aim is to develop Bayesian methods to obtain high-resolution molecular structures and dynamics from sparse and noisy experimental data. A particular focus is to develop accurate uncertainty models to be included within the probabilistic approach.
More details: www.mpibpc.mpg.de/9660732/SM-Ultrafast-XRay-Diffraction
The successful candidate has a keen interest and strong skills in computational physics and probability theory, and also a strong interest in interdisciplinary research and collaboration with experimental groups.
PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field.
PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.
Payment and benefits are based on the TVöD guidelines. The starting date is flexible.
The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German!
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.
Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!
Max Planck Institute for Biophysical Chemistry Department „Theoretical and Computational Biophysics“ Prof. Dr. Helmut Grubmüller Am Fassberg 11 37077 Göttingen Germany
Web: www.mpibpc.mpg.de/grubmueller
Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.

Postdoc at lino Biotech AG in Zurich

Position: Postdoc at lino Biotech AG in Zurich

Description: This postdoctoral project represents an excellent opportunity to perform innovative research in industry and academia. It evolved from fundamental research at Roche and ETH Zurich and is now commercialized by the technology spin-off lino Biotech AG. The position is part of a postdoctoral research collaboration between Roche and lino Biotech in order to bring this technology to the next level: a potential application in a clinical setting. The project is supervised by lino Biotech, Roche, as well as Prof. Janos Vörös from the ETH Zurich. The majority of the work will be done at lino Biotech in Zurich while some research also will be performed at Roche in Basel. In this research, you will concentrate on site-directed surface immobilization of proteins; study and characterize the binding of ligands with the immobilized proteins and develop a multiplexed antibody platform for the diagnosis and treatment monitoring of neurogenerative diseases in clinical relevant body fluids. You will also have the chance to communicate your results to the scientific community and to work in a supportive, highly collaborative, and energetic environment. The position is funded for a two years period. The place of employment is Zurich. Background: You are someone who wants to influence your own development. You are looking for an environment where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

For this position, you will need a PhD degree in science (biochemistry, chemistry, biology, systems biology, biomedical engineering, or related areas) and bring several of the following qualifications: Skills: ● Advanced knowledge of experimental surface chemistry (i.e. polymer chemistry, protein modification and immobilization) ● Experience in bioorthogonal coupling chemistries ● Experience with label-free technologies (e.g. SPR, BLI), biological assay development and the corresponding data processing ● Strong knowledge of interaction analysis, analysis of -omics data and multiplex sensor arrays and relevant statistical background to apply to these areas ● An outstanding track record documenting relevant experience in these areas; accustomed to work in an interdisciplinary team; good interpersonal skills/ability to build good working relation; excellent English skills ● Optional: ability to write small scripts and automate data processing and workflows in a suitable programming language ● Optional: Experienced in working under biosafety level 2 We look forward to receiving your application including a letter of motivation, CV, list of publications and contact details of your referees.

 

Contact Person: Dr. Volker Gatterdam, Alliance Manager Email: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!