Ph.D. student (f/m/d) or PostDoc (f/m/d) To study amino acid transporter structure and function

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Our team is looking for a

Ph.D. student (f/m/d) or PostDoc (f/m/d)
To study amino acid transporter structure and function

A Ph.D. student position (65% TVL E13) for 36 months or a PostDoc position (100% TVL E13) for 27 months is available in the group of PD Dr. Ulrich Hammes at the Chair of Plant Systems Biology at the School of Life Sciences at TUM in Freising-Weihenstephan jointly with the group of Prof. Olga Boudker at Weill Cornell Medical College.

Research and Tasks

We want to study proton-coupled amino acid transporters from plants. We want to solve the structures of several transporters to understand their transport mechanisms and biophysical properties. The insights gained from the biochemical work will be transferred to plants with the aim of increasing nitrogen efficiency by improving transport through rational design.

Your Profile

A strong background and interest in protein expression, different expression systems, and purification of membrane proteins, as well as transport physiology, particularly electrophysiology, to characterize transporters are indispensable. A keen interest in plants is desirable. The funding scheme requires the successful candidate to spend time in both institutions. The will to travel and exposure to different lab and social environments is also of critical importance.

We offer

Weill Cornell Medical College and TUM are elite research environments and provide access to state-of-the-art techniques and equipment required to perform research at the leading edge of science.

Website of the Chair of Plant Systems Biology at TUM: http://sysbiol.wzw.tum.de

Website of the Boudker lab at Weill Cornell Medical College: https://www.boudkerlab.com

Application

We are looking forward to your application, including a letter of motivation describing your skills and research interest, your CV, and contact information for two references.

Please send your application documents in a single PDF to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

The position is available immediately. The selection process will remain open until a suitable candidate is found.

TUM aims to increase the proportion of women; qualified women are therefore strongly encouraged to apply.

The position is suitable for severely disabled persons. Severely disabled applicants will be given preference in the event of otherwise essentially equal suitability, ability and professional performance.

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity/Minorities/Females/Vet/Disabled employer.

Data Protection Notice

As part of your application for a position at the Technical University of Munich (TUM), you will be providing personal data. Please refer to our data protection notice in accordance with Article 13 of the General Data Protection Regulation (GDPR) regarding the collection and processing of personal data in the context of your application. By submitting your application, you confirm that you have read TUM's data pro

PhD position (m/f/d) in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases (65% TV-L E13, 36 month).

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PhD position (m/f/d) in Experimental Molecular Biophysics of Protein Misfolding in Neurodegenerative Diseases (65% TV-L E13, 36 month).

The Kozuch group investigates the function of biomedically relevant (membrane) proteins with a special focus on electrostatic interactions that shape the formation of functional motifs. The methodological approach is based on a combination of (nanoscopic) vibrational spectroscopy supplemented by the use of model membrane systems, biochemical methods and computer-aided simulations. After completing his doctoral thesis in biophysical chemistry at the Technical University of Berlin, Dr. Jacek Kozuch did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at Freie Universität Berlin.

This DFG-funded project aims to research how specific interactions with membranes for folding or misfolding of, e.g., β-amyloid or islet amyloid polypeptide can lead to neurodegenerative diseases. For this purpose, surface-enhanced (SEIRAS) and AFM-based nano-infrared spectroscopy (nanoIR) in combination with model membrane systems will be used to track folding trajectories and control them through various boundary conditions.

We offer:

  • the opportunity for a PhD within the stimulating, interdisciplinary and

  international environment of Freie Universität Berlin,

  • the entry into fascinating and biomedically relevant topics of molecular

  Biophysics,

  • the use and further development of modern vibrational spectroscopic methods.

Requirements and Qualifications

Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, biochemistry or in one of the related natural sciences.

We are looking for candidates with:

Experience with vibrational spectroscopic methods and/or atomic force microscopy; handling biological samples (e.g., proteins); willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; fun and fascination with science, especially in the field of molecular biophysics.

The area of ​​responsibility includes:

  • the independent conduction of this scientific project,
  • the biochemical preparation of protein/peptide samples and the construction of

  membrane model systems,

  • the implementation of nanoscopic and surface-enhanced infrared spectroscopy

  measurements,

  • participation in international conferences.

Selection process

Please contact Dr. Jacek Kozuch if more information is required (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! / +49 (0)30 838 64888) or visit the FU Berlin homepage: https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/wiss/20_fb-physik/PH-KO5464-5.html

Applications (including cover letter, CV, certificates, one letter of recommendation as a single PDF) should be sent electronically by e-mail to Dr. Jacek Kozuch: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!">Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.

PhD Student or Postdoc (f/m/x) “Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

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PhD Student or Postdoc (f/m/x) “Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

YOUNG SCIENTISTS

Job Code: 60-23

Job Offer from December 21, 2023

The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.

The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) is inviting
applications for a

PhD Student or Postdoc (f/m/x)
in the field of
“Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

Possible projects are variational free energy methods, thermodynamics of solvation shells, Markovian thermodynamics, as well as functional mechanisms of the ribosome, fatty acid synthase, CRISPR/Cas, or intrinsically disordered proteins.

Please indicate in your application which of the above listed projects is most intriguing for you.

Your profile

The successful candidate has a keen interest and strong skills in computational molecular physics and statistical mechanics, and also a great interest in interdisciplinary research and collaboration with experimental groups.

PhD students hold (or expect to complete soon) a Masters or equivalent degree in physics, mathematics or any related field; correspondingly, Postdocs hold a PhD or equivalent degree in the above mentioned fields.

What we offer

  • State of the art on-site high performance / GPU compute facilities
  • Competitive research in an inspiring, world-class environment
  • A wide range of offers to help you balance work and family life
  • Further training opportunities and free in-house language courses

The group language is English, so no German language skills are required – but it is a great opportunity for you to learn German! The historic city of Göttingen, located in the heart of Germany, offers great outdoors and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.

Position details

PhD students will have the opportunity to participate in one of several available PhD programs, with three years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and, therefore, encourages applications from such qualified individuals. The Max Planck Society strives for diversity and gender equality and welcomes applications from all backgrounds.

Application

Applications will be reviewed on a rolling basis until the position is filled. Please submit your application including a cover letter (explaining background and motivation), a CV and transcripts (translated to English or German, if applicable) preferably via e-mail and as a single PDF file to:

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Max-Planck-Institute for Multidisciplinary Sciences
Department of Theoretical and Computational Biophysics
Prof. Dr. Helmut Grubmüller
Am Faßberg 11
37077 Göttingen
Germany

Social Media: @CompBioPhys

PhD position (m/f/d) in Molecular Biophysics of Antibiotic Resistance (65% TV-L E13, 36 month).

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PhD position (m/f/d) in Molecular Biophysics of Antibiotic Resistance (65% TV-L E13, 36 month).

The Kozuch group investigates the function of (membrane) proteins that are relevant for the evolution of antimicrobial resistance. Particular attention is paid to how electrostatic interactions shape the formation of functional motifs. The methodological approach is based on a combination of vibrational spectroscopy and computer-aided simulations supplemented by the use of model membrane systems and biochemical methods. Dr. Jacek Kozuch completed his doctoral thesis in biophysical chemistry at the Technical University of Berlin, then did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at the Freie Universität Berlin.

This DFG-funded project aims to research how physical/non-covalent interactions in proteins contribute to the evolution of antibacterial resistance. By combining theoretical and experimental approaches, methods of computer-assisted vibrational spectroscopy will be developed in order to understand clinically relevant evolutionary trajectories.

Relevant publications:

https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.1c00578

https://pubs.acs.org/doi/abs/10.1021/acscentsci.1c00880

We offer:

  • the opportunity to conduct a doctorate within the stimulating, interdisciplinary and international environment of Freie Universität Berlin,
  • the entry into fascinating and biomedically relevant topics of molecular biophysics,
  • the development of modern, experimental and computer-aided vibrational spectroscopy.

Requirements and Qualifications

Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, bioinformatics or in one of the related natural sciences.

We are looking for candidates with:

Experience with molecular dynamics simulations and/or vibrational spectroscopy; Knowledge and enjoyment in coding with Python; Willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; Fun and fascination with science, especially in the field of molecular biophysics.

The area of ​​responsibility includes:

  • the independent processing of this scientific project,
  • the implementation of molecular dynamics simulations of biomolecules in particular,
  • infrared spectroscopic measurements in external electric fields (vibrational Stark spectroscopy),
  • willingness to participate in international conferences,
  • the opportunity for a doctorate is given as part of the third-party funded research project.

Selection process

Please contact Dr. Jacek Kozuch if more information is required (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! / +49 (0)30 838 64888) or visit the FU Berlin homepage: https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/wiss/20_fb-physik/PH-DFG-KO5464-4-1.html

Applications should be sent electronically until Feb. 28, 2022, indicating the reference code DFG-KO5464/4-1, (preferably as one PDF) to Dr. Jacek Kozuch: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.

PhD Position Topic: Investigation of the structure and dynamics of the ghrelin/GHS receptor complex

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PhD Position

Topic: Investigation of the structure and dynamics of the ghrelin/GHS receptor complex

beginning: at the earliest possible date, payment according to TVL13 (65%)

working group: Prof. Dr. Daniel Huster, Institute of Medical Physics and Biophysics,

                              Härtelstr. 16-18, 04107 Leipzig

The peptide hormone ghrelin plays a key role in food intake and body weight regulation. Ghrelin binds and activates the GHS receptor (GHSR) representing an important pharmacological target. In the project, structural details of the dynamic interaction of ghrelin with GHSR and its conformational dynamics in different states of activation will be studied. We use a combination of experimental methods of nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulation tools in collaboration with projects of the CRC 1423 “Structural Dynamics of GPCR Activation and Signaling”. Alterations of GHSR structure and dynamics, which occur upon binding of the agonist ghrelin, will be studied to address the mechanism of receptor activation and signal transduction to downstream transducer proteins. To understand the high basal activity of GHSR, we will plan to study the loss-of-constitutive-activity Ala204Glu GHSR mutant as downregulation of this basal activity represents a pharmacological goal.

The AG Huster at the Institute of Medical Physics and Biophysics is an international group of ~15 people from different backgrounds. Our values are gender equality, mutual appreciation and support of each other to create a constructive and positive working atmosphere. A video of our group can be found here:

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The candidate should hold a master’s degree in biochemistry, chemistry, biophysics or a relevant field.

Applications with a cover letter, a CV, all relevant university certificates and contact information of potential referees should be sent as a single PDF file per email to Daniel Huster, Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.

PhD Position in Experimental Molecular Biophysics

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a homebuilt IR spectrometer with a laser-excited temperature-jump will be used to monitor submillisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately.
We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.
The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available. Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Related publications:
Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534
Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J
Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IRspectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199

Further information: www.biophysik.uni-konstanz.de

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

 

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

As part of the Cluster of Excellence ‘Unifying Systems in Catalysis’ (UniSysCat), the Horch research group ‘Ultrafast Dynamics in Catalysis’ aims to understand complex catalytic systems and superordinate reaction networks by using an integrated approach of advanced spectroscopic and theoretical methods. In particular, we are interested in metalloenzymes – huge metal-containing proteins that catalyse, e.g., the conversion of small molecules like H2 and CO2.

More details about the Horch research group and UniSysCat, can be found here:

https://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-horch/

https://www.unisyscat.de/people/current-group-leaders/horch-marius/

Project Description

To establish a “greener” chemistry based on living cells, we envisage the design of a cellular system that uses waste material and unlimited sun light for sustainable hydrogen production. Developing such a system requires a detailed understanding of all involved processes on the molecular and cellular level. Together with multiple partners, the successful candidate will develop a multichannel in vivo spectroscopy approach to target the involved biological macromolecules, relevant cytoplasmic factors, and the interplay of these two types of cellular key determinants. Focusing on the hydrogen-producing enzyme, a [NiFe] hydrogenase, this strategy will expand previously established in vivo spectroscopic strategies by introducing ultrafast and multidimensional infrared techniques that yield details insights into structure, dynamics, and environmental interactions. In total, this approach will provide a guideline for the rational design of cellular catalytic systems.

Relevant Publications

https://doi.org/10.1002/anie.201002197

https://doi.org/10.1039/C5CP02447A

https://doi.org/10.1039/C9SC02851J

Field of Work

- Ultrafast nonlinear infrared spectroscopic experiments (2D-IR and IR-IR pump-probe)

- Execution of such experiments at international research facilities

- Analysis and interpretation of spectroscopic data

- Interdisciplinary cooperation with other members of the overarching team project

- Manipulation and handling of delicate biological samples supplied by collaboration partners

- If beneficial, calculation of infrared spectroscopic observables by quantum chemical methods

- Writing of scientific articles for publication in international peer-reviewed journals

- Presentation of research results at international scientific conferences

We Offer

We offer a position in an exciting and challenging project with the opportunity to obtain a PhD. The project will be pursued in a dynamic, international, and cooperative team of scientists from different fields of research. The project is also part of UniSysCat, which provides the opportunity to engage in interdisciplinary collaborations and build scientific networks. As a first-class location for science and a vibrant global city, Berlin offers an ideal framework.

Requirements

Master’s degree (or equivalent) in the field of physics, physical chemistry, biophysics or similar

Desirable Qualification

Expertise and experience in the following areas is desirable, but knowledge in all them of them is not mandatory. Applications from candidates that are willing to learn about the listed aspects are welcome

- Excellent university degree

- Experience with infrared spectroscopy or vibrational spectroscopy in general

- Experience with ultrafast nonlinear spectroscopy and data analysis

- Experience with (pulsed) laser sources and (nonlinear) optics

- Experience with quantum chemical calculations

- Experience with the handling of biological and/or oxygen-sensitive samples 

- Knowledge in biological, inorganic, and/or photo chemistry

- Programming skills, preferably in Python

- Ability to work independently and as part of an interdisciplinary team

- Creativity, enthusiasm, and a genuine interest in the advertised project

- Fluency in English (spoken and written)

 

Starting Date

As soon as possible

Application Deadline

13 March 2023. Applications sent after the deadline will be considered until the position is filled.

Funding

TV-L E13 (67 %) until 31 December 2025, funding by the DFG via UniSysCat, funding extension from other sources is possible

Selection Process

Please send your documents and requests to Dr. Marius Horch (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!)

Further details can be found here:

https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/english/PH-Horch-UniSysCat-Cells-2023-E.html

PhD Position in Biophysical Chemistry

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function. Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.

We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! publications:
Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857
Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174

Further information: www.biophysik.uni-konstanz.de
Distributed: 1.12.2020

PhD Project on Interaction of Rhodopsin and Cryptochrome as the Basis for Opto-Magnetic sensing in Birds

PROJECT DESCRIPTION
Magnetosensing is mandatory for seasonal long distant flights of birds and butterflies from north to south
and back and to find the home places of previous years. During the past 40 years strong evidence has
been collected that for magnetic orientation blue light sensitive Cryptochromes within the retina of the
eyes are responsible.
However, since birds are able to navigate at very low light intensities during the night an interaction of the
abundant rhodopsins with the only scarcely expressed Cryptochromes has been suggested.
In the open project unusual rhodopsins of birds and butterflies and their interaction with Cryptochromes
will be studied and characterized in detail in order to understand animal magnetic sensing. Behavioral
studies will be carried out in collaboration with behavioral zoologists.
KEYWORDS
Magnetosensing, Photobiology, unusual rhodopsins, flavin-based photoreceptors, UV-Vis and infrared
spectroscopy, EPR, ultra-fast spectroscopy.
Entry requirements
The applicant needs a MSc. degree (or equivalent) in biochemistry, biophysics, biology or related fields.
Basic skills in molecular biology are mandatory. The applicant should be prepared to work in a highly
interdisciplinary team with strong international collaborations.
LOCATION
Humboldt Universität zu Berlin, Institute of Biology, Experimental Biophysics, Invalidenstraße 42, D-10115
Berlin
STARTING DATE
Between August and December 2023
FUNDING
Four years of funding (3+1, three years with the possibility to extend for one year)

2023-HFA-Advertised-position_Hegemann.pdf (hector-fellow-academy.de)

PhD Position in Super-resolution RNA Imaging

Topic
Genetically encodable fluorescence markers for imaging of specific RNA molecules in live  cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab,  IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell super‐ resolution localization microscopy  applications. 

Candidate
We are looking for an excellent, highly motivated person with a degree in (bio)physics,  physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis. 

Contact
Prof. Dr. Gerd Ulrich Nienhaus (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!) Institute of Applied Physics, KIT, 76131 Karlsruhe

References
Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke. 
SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562  (2019)

Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün, 
F., Nienhaus, K., Nienhaus,  G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with  fast exchange kinetics.  Nature Biotechnol., in press. 

http://www.aph.kit.edu/nienhaus/

Doctoral & Postdoctoral Positions in Computational Membrane Biophysics in Erlangen

 

Doctoral & Postdoctoral Positions in Computational Membrane Biophysics in Erlangen

Applications are invited for PhD positions/Postdoc/Senior Postdoc in our lab for theoretical and computational membrane biophysics at the Friedrich-Alexander University of Erlangen-Nürnberg, Germany.

Plasma membranes and in general biomembranes establish and maintain differences in composition between the cell or organelle interior and exterior. Biomembranes are the site for cell-cell recognition, they allow active and passive transport of material into and out of the cell, and they harbour proteins as initiators of signal transduction pathways.

Projects address the physico-chemical driving forces for the establishment of membrane domains within the immune cell plasma membrane, and their role for sensing of external signals by immune receptors and signal transduction, as well as membrane remodeling. The aim is to shed light on the cooperative action of proteins and lipids in shaping biomembrane structure.

Central questions for our research are

  • How are external signals sensed by immune cells, how do lipids contribute to signal transfer across the cell membrane, and how do lipids modulate immune cell activation?
  • What is the role of plasma membrane domains in immune cell activation?
  • Can we modulate or control immune cell function by cell membrane composition?

and more general

  • What are the physical driving forces for membrane domain formation?
  • How is domain formation linked to plasma membrane asymmetry?
  • How are plasma membrane asymmetry and biological membrane processes interlinked?

Applicants for doctoral positions:

Candidates should preferably hold a master degree in bio-/physics, theoretical/computational chemistry, life sciences or similar and a strong interest in interdisciplinary projects and collaborations to medical/immunology groups.

 

Postdoc applicants:

The successful applicant has a keen interest and strong skills in methods from statistical and computational physics, in particular atomistic and coarse-grained molecular dynamics simulations. The project involves close collaboration with immunology groups. The Postdoc will have the opportunity to participate in a research cluster studying the structure and function of immune domains.

Other requirements:

High level of English and good communication skills; effective team working.

Erlangen is a center for immunobiology with more than 70 groups focusing on immunological topics. In addition, since 2021, the University of Erlangen hosts a National High Performance Computing Center (hpc.fau.de) with a focus on atomistic simulations.

Interested candidates should send one pdf document containing a cover letter, CV, and certificates to

Prof. Dr. Rainer Böckmann

Computational Biology

Staudtstr. 5, 91058 Erlangen, Germany

www.biomemphys.nat.fau.de

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.

Postdoc at lino Biotech AG in Zurich

Position: Postdoc at lino Biotech AG in Zurich

Description: This postdoctoral project represents an excellent opportunity to perform innovative research in industry and academia. It evolved from fundamental research at Roche and ETH Zurich and is now commercialized by the technology spin-off lino Biotech AG. The position is part of a postdoctoral research collaboration between Roche and lino Biotech in order to bring this technology to the next level: a potential application in a clinical setting. The project is supervised by lino Biotech, Roche, as well as Prof. Janos Vörös from the ETH Zurich. The majority of the work will be done at lino Biotech in Zurich while some research also will be performed at Roche in Basel. In this research, you will concentrate on site-directed surface immobilization of proteins; study and characterize the binding of ligands with the immobilized proteins and develop a multiplexed antibody platform for the diagnosis and treatment monitoring of neurogenerative diseases in clinical relevant body fluids. You will also have the chance to communicate your results to the scientific community and to work in a supportive, highly collaborative, and energetic environment. The position is funded for a two years period. The place of employment is Zurich. Background: You are someone who wants to influence your own development. You are looking for an environment where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

For this position, you will need a PhD degree in science (biochemistry, chemistry, biology, systems biology, biomedical engineering, or related areas) and bring several of the following qualifications: Skills: ● Advanced knowledge of experimental surface chemistry (i.e. polymer chemistry, protein modification and immobilization) ● Experience in bioorthogonal coupling chemistries ● Experience with label-free technologies (e.g. SPR, BLI), biological assay development and the corresponding data processing ● Strong knowledge of interaction analysis, analysis of -omics data and multiplex sensor arrays and relevant statistical background to apply to these areas ● An outstanding track record documenting relevant experience in these areas; accustomed to work in an interdisciplinary team; good interpersonal skills/ability to build good working relation; excellent English skills ● Optional: ability to write small scripts and automate data processing and workflows in a suitable programming language ● Optional: Experienced in working under biosafety level 2 We look forward to receiving your application including a letter of motivation, CV, list of publications and contact details of your referees.

 

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