Wissenschaftliche*r Mitarbeiterin*Mitarbeiter (m-w-d)

The research group of Jun.-Prof. Dr. Carla Schmidt at the Martin Luther University in Halle is looking for a PhD student. The position is available in Project A4 (Characterizing the interactions of proteins with polyphilic detergents and lipids and their impact on membrane self-assembly) of the DFG-funded research training group (RTG) 2670 "Beyond Amphiphilicity: Self-Organization of Soft Matter via Multiple Noncovalent Interactions" (https://beam.uni-halle.de/).

The project involves mainly native mass spectrometry but also complementary biophysical techniques.

The current application deadline is May 16, 2021. The job advertisement can be found at:
http://www.verwaltung.uni-halle.de/dezern3/Ausschr/21_5_4580_21_D_engl.pdf
http://www.verwaltung.uni-halle.de/dezern3/Ausschr/21_5_4580_21_D_deu.pdf

PhD Position in Biophysical Chemistry

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function. Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study molecular interaction mechanisms with infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.

We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein! publications:
Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857
Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174

Further information: www.biophysik.uni-konstanz.de
Distributed: 1.12.2020

Scientific Project Manager & Science Writer

The Biophysics group of Professor Sandro Keller at the Institute of Molecular Biosciences (IMB) of the University Graz, Austria is looking for a

Scientific Project Manager & Science Writer

(preferably full-time employment according to FWF standard salary for postdocs; initially fixed term for two years with possible extension; position to be filled as soon as possible)

We are looking for a new team member with a keen interest and a strong track record in communicating research results. In your role as Scientific Project Manager & Science Writer, you will be responsible for coordinating research projects, visualising results, and writing manuscripts in close cooperation with laboratory researchers at all career stages. You will work in a dynamic, inspiring, and interdisciplinary environment amongst enthusiastic scientists dedicated to elucidating the molecular details of how membrane proteins function in the complex milieu of a lipid membrane. You will support our research projects by providing strategic input and feedback and by assisting with the presentation and communication of our latest scientific findings.

Your responsibilities

·     Science writing for progress reports, grant applications, and peer-reviewed publications
·     Visualising research results and models for written publications and oral presentations
·     Setting up and maintaining a website and contributing to science communication
·     Coordinating and managing research projects (mostly funded by third parties)
·     Identifying grant opportunities and possibilities for collaboration
·     Attending and contributing to group and collaboration meetings
·     Participating in third-mission tasks and public relations

Your profile

·     Doctoral degree or equivalent in the life sciences or a related scientific field
·     Excellent writing skills as required for scientific publications and grant applications
·     Very good written and spoken English language skills, at least good command of German
·     Facility with computer programs for visualising and presenting research results and models
·     Ability to communicate effectively with colleagues, collaborators, and other scientists
·     Experience in science management and communication (e.g., public relations, social media)
·     Self-driven, independent, and responsible way of working

Our offer

The minimum salary corresponds to the FWF standard salary for postdocs; the actual salary may be higher if there are previous employment periods eligible for inclusion. In case of success, the initial two-year contract will be extended. We offer an exciting job with a lot of responsibility and variety. You can expect an enjoyable work atmosphere, flexible work hours, and numerous possibilities for further education and personal development. We welcome applications from persons with disabilities who meet the requirements of the advertised position.

Your application

Your application should consist of a single PDF file containing (1) a motivation letter of no more than two pages, (2) a CV including a list of publications, and (3) the names and contact details of at least two individuals who can provide reference attesting to your professional abilities and qualifications. Please e-mail your application before 15th May 2021 to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.

PhD Position in Super-resolution RNA Imaging

Topic
Genetically encodable fluorescence markers for imaging of specific RNA molecules in live  cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab,  IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell super‐ resolution localization microscopy  applications. 

Candidate
We are looking for an excellent, highly motivated person with a degree in (bio)physics,  physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis. 

Contact
Prof. Dr. Gerd Ulrich Nienhaus (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!) Institute of Applied Physics, KIT, 76131 Karlsruhe

References
Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke. 
SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562  (2019)

Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün, 
F., Nienhaus, K., Nienhaus,  G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with  fast exchange kinetics.  Nature Biotechnol., in press. 

http://www.aph.kit.edu/nienhaus/

Masterarbeit (M.Sc., M.Ing.) "Numerische Simulationen für additive Fertigungsverfahren in der pharmazeutischen Technologie"

Im Rahmen eines Kooperationsprojekts bietet die Abteilung für Pharmazeutische Technologie und Biopharmazie der Christian-Albrechts-Universität zu Kiel ab sofort (Sommersemester 2021) eine Masterarbeit (M.Sc., M.Ing.) an im Bereich

Numerische Simulationen für additive Fertigungsverfahren in der pharmazeutischen Technologie

Während additive Fertigungsverfahren zur Herstellung medizinischer Geräte umfassend erprobt sind, erfordert deren Nutzung zur Entwicklung wirkstoffhaltiger Darreichungsformen weitere Forschungsanstrengungen. Moderne Technologien ermöglichen die Produktion von komplexen Strukturen mit hoher Auflösung unter Verwendung neuartiger Materialien. Dieser Fortschritt offenbart für die Entwicklung von Arzneimitteln zur Inhalation vielfältige, neuartige Möglichkeiten. Um ein umfassenderes Verständnis zu Einflussfaktoren und Wechselwirkungen aufzubauen und additive Fertigungstechniken mit klassischen Pharma- und Verfahrenstechniken zu verknüpfen, werden numerische Simulationen eingesetzt.

Fragestellungen der Masterarbeit:

- Evaluierung des Verhaltens partikulärer Strukturen mithilfe von Simulationsmodellen in verschiedenen Inhalationsfragestellungen (Partikelwechselwirkungen, Partikelbewegung etc.)

- Analyse und Weiterentwicklung bestehender Simulationsmodelle (Rocky DEM)

- Integration von in-silico Parametern in additive Fertigungsprozesse

Ihr Profil:

- Student*in im Bereich Ingenieurwesen, Informatik oder in vergleichbaren naturwissenschaftlichen Studiengängen wie z.B. Life Science, Biotechnologie, Pharmazie

- Erste Erfahrungen mit numerischer Simulation und entsprechender Software

- Interesse an mathematischen Zusammenhängen und interdisziplinärer Teamarbeit

- Kenntnisse in einer der gängigen CAD-Software

- Gute Englischkenntnisse in Wort und Schrift

Im Rahmen dieser Masterarbeit arbeiten Sie an Grundlagenforschung in einem multidisziplinären und internationalen Umfeld. Sie erhalten Einblicke sowohl in ein großes Pharmaunternehmen als auch in die Forschungsaktivitäten der Pharmazie. Die Schnittstellen unterschiedlicher, moderner Technologien und deren Integration in pharmazeutische Prozesse zur Entwicklung und Herstellung von Arzneimitteln steht im Fokus Ihrer Masterarbeit. I Christian-Albrechts-Universität zu Kiel, Abteilung für Pharmazeutische Technologie und Biopharmazie, Grasweg 9a, 24118 Kiel, Germany

Bitte bewerben Sie sich direkt bei Prof. Dr. Regina Scherließ (Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!) Fragen zu dieser Position beantwortet gerne: Simon Bock, Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.d

Postdoc at lino Biotech AG in Zurich

Position: Postdoc at lino Biotech AG in Zurich

Description: This postdoctoral project represents an excellent opportunity to perform innovative research in industry and academia. It evolved from fundamental research at Roche and ETH Zurich and is now commercialized by the technology spin-off lino Biotech AG. The position is part of a postdoctoral research collaboration between Roche and lino Biotech in order to bring this technology to the next level: a potential application in a clinical setting. The project is supervised by lino Biotech, Roche, as well as Prof. Janos Vörös from the ETH Zurich. The majority of the work will be done at lino Biotech in Zurich while some research also will be performed at Roche in Basel. In this research, you will concentrate on site-directed surface immobilization of proteins; study and characterize the binding of ligands with the immobilized proteins and develop a multiplexed antibody platform for the diagnosis and treatment monitoring of neurogenerative diseases in clinical relevant body fluids. You will also have the chance to communicate your results to the scientific community and to work in a supportive, highly collaborative, and energetic environment. The position is funded for a two years period. The place of employment is Zurich. Background: You are someone who wants to influence your own development. You are looking for an environment where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

For this position, you will need a PhD degree in science (biochemistry, chemistry, biology, systems biology, biomedical engineering, or related areas) and bring several of the following qualifications: Skills: ● Advanced knowledge of experimental surface chemistry (i.e. polymer chemistry, protein modification and immobilization) ● Experience in bioorthogonal coupling chemistries ● Experience with label-free technologies (e.g. SPR, BLI), biological assay development and the corresponding data processing ● Strong knowledge of interaction analysis, analysis of -omics data and multiplex sensor arrays and relevant statistical background to apply to these areas ● An outstanding track record documenting relevant experience in these areas; accustomed to work in an interdisciplinary team; good interpersonal skills/ability to build good working relation; excellent English skills ● Optional: ability to write small scripts and automate data processing and workflows in a suitable programming language ● Optional: Experienced in working under biosafety level 2 We look forward to receiving your application including a letter of motivation, CV, list of publications and contact details of your referees.

 

Contact Person: Dr. Volker Gatterdam, Alliance Manager Email: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

PhD Position in Experimental Molecular Biophysics

Applications are invited for a PhD position in the research group of Professor Karin Hauser at the University of Konstanz. The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a homebuilt IR spectrometer with a laser-excited temperature-jump will be used to monitor submillisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately.
We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.
The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available. Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Related publications:
Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534
Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J
Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IRspectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199

Further information: www.biophysik.uni-konstanz.de