PhD Position in Super-resolution RNA Imaging
Topic
Genetically encodable fluorescence markers for imaging of specific RNA molecules in live cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab, IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell super‐ resolution localization microscopy applications.
Candidate
We are looking for an excellent, highly motivated person with a degree in (bio)physics, physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis.
Contact
Prof. Dr. Gerd Ulrich Nienhaus (This email address is being protected from spambots. You need JavaScript enabled to view it.) Institute of Applied Physics, KIT, 76131 Karlsruhe
References
Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke.
SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562 (2019)
Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün,
F., Nienhaus, K., Nienhaus, G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with fast exchange kinetics. Nature Biotechnol., in press.